Table 1. Prognostic factors favoring upfront debulking surgery in patients with high-grade serous ovarian cancer.
| Patient’s profile |
| Age <65 years of age |
| BMI <30 kg/m2 |
| No comorbidities |
| No severe illness |
| Stage of the disease |
| < IIIC |
| Histology |
| High-grade serous ovarian cancer less favorable for upfront debulking surgery |
| Biomarkers |
| Ca-125 <100–300 IU/L; useful postoperative biomarker |
| HE4↓ (<277 pmol/L) |
| Albumin >25 g/L |
| Genomic and other factors |
| BRCA: no mutations |
| TILs ↓ levels |
| cfDNA↓ levels |
| Spread of the disease |
| Resectable disease |
| No extent of the disease over diaphragm Ascites <1 L |
| No lymph node involvement; no CLN involvement |
| No liver, omental nor spleen metastasis |
| Minimal small and low bowel infiltration |
| No macroscopic residual disease can be performed |
BMI, body mass index; Ca-125, cancer antigen 125; HE4, human epididymis 4; TILs, tumor-infiltrating lymphocytes; cfDNA, cell-free DNA; CLN, celiac lymph node.