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. 2020 Dec 17;25(2):1012–1023. doi: 10.1111/jcmm.16165

FIGURE 2.

FIGURE 2

SAL attenuated renal oxidative stress in db/db mice. A(i), Kidney sections also were used for co‐staining transferase dUTP nick end labelling (TUNEL) and wild‐type 1 (WT‐1) to determine the rate of apoptosis in podocytes. A(ii), Quantification of TUNEL‐positive cells per glomerulus and the number of podocytes per glomerulus. ** P < .01, *** P < .001 vs vehicle‐treated db/db mice (n = 6). B(i), representative kidney sections immunostained for 8‐OHdG to show oxidative stress of kidney tissue (original magnification × 400, Bar = 100 μM, the red arrow indicates the positive nuclei). B(ii), quantification of 8‐OHdG‐positive cells fraction. C, Effects of SAL on GSH level in renal cortex from different intervened group. D, Effects of SAL on malondialdehyde (MDA) activity in renal cortex from different intervened groups; *** P < .001 vs vehicle‐treated db/db mice (n = 6)