FIGURE 6.

STAT3 signalling acts downstream of CD63 in HCC. A, MHCC‐LM3 cells were treated with BP‐1‐102 at the indicated concentrations for 12 h, and Western blot analysis was conducted to determine the changes of p‐STAT3 (Y705) and total STAT3 expression. B and C, the indicated HCC cells were cultured in medium supplemented with BP‐1‐102 (10 μmol/L) or DMSO, and CCK‐8 assays and colony formation assays were carried out to assess the influence of BP‐1‐102 on the effects of CD63 silencing in proliferation ability of MHCC‐LM3 cells. D, after treating the above HCC cells with BP‐1‐102 (10 μmol/L) or DMSO, transwell migration assays were performed to confirm whether CD63 inhibited HCC cell migration via inactivating STAT3