Table 1.
Participant Characteristics at Baseline in 6,803 Men, Aged 60–69 Years, From the CT Arm of the National Lung Screening Trial
| Characteristic | All (n = 6,803) | Survivors (n = 6,168) | Deceased (n = 635) | HR (95% CI) | p-Value |
|---|---|---|---|---|---|
| Age ± SD (y) | 63.7 ± 2.8 | 63.6 ± 2.8 | 64.4 ± 2.9 | 1.10 (1.07, 1.13) | <.001 |
| BMI ± SD (kg/m2) | 27.9 ± 4.5 | 27.9 ± 4.3 | 28.0 ± 5.4 | 1.00 (0.99, 1.02) | .711 |
| Caucasian | 6,237 (92.0) | 5,661 (92.1) | 576 (91.0) | 0.87 (0.66, 1.14) | .309 |
| Pack-years of smoking | 61.7 ± 26.8 53 (43, 75)a | 61.1 ± 26.6 53 (42, 74)a | 67.6 ± 28.2 60 (46, 83)a | 1.01 (1.01, 1.01) | <.001 |
| Type 2 diabetes | 812 (12.0) | 699 (11.4) | 113 (17.8) | 1.64 (1.34, 2.02) | <.001 |
| Chronic lung disease | 1,656 (24.4) | 1,454 (23.6) | 202 (31.8) | 1.48 (1.25, 1.75) | <.001 |
| Cardiovascular disease | 3,274 (48.1) | 2,924 (47.4) | 350 (55.1) | 1.35 (1.15, 1.57) | .002 |
| Cancer | 134 (2.0) | 119 (1.9) | 15 (2.4) | 1.20 (0.72, 2.01) | .477 |
| Skeletal muscle area (cm2) | 16.0 ± 3.50 | 16.1 ± 3.48 | 15.3 ± 3.61 | 0.82 (0.76, 0.88)b | <.001 |
| Skeletal muscle density (HU) | 49.1 ± 7.0 | 49.2 ± 6.9 | 48.4 ± 7.6 | 0.90 (0.84, 0.98)b | .010 |
Notes: BMI = body mass index; CI = confidence interval; CT = computed tomography; HR = hazard ratio; HU = Hounsfield units. Mean ± SD for continuous variables; n (%) for categorical variables. p-values are calculated using the unadjusted Cox proportional hazards model.
aMedian (first quartile, third quartile).
bHR per SD.