TABLE 2.
Characteristics and treatment outcomes of registered fresh ART cycles in assisted reproductive technology, Japan, 2018
| Variables | IVF–ET | Split | ICSI | GIFT | Frozen oocyte | Others a | Total | |
|---|---|---|---|---|---|---|---|---|
| Ejaculated sperm | TESE | |||||||
| No. of registered cycles | 88 072 | 28 546 | 127 974 | 2339 | 25 | 644 | 3811 | 251 411 |
| No. of egg retrieval | 86 021 | 28 267 | 126 422 | 2337 | 25 | 638 | 3692 | 247 402 |
| No. of fresh ET cycles | 20 403 | 5058 | 23 981 | 530 | 25 | 0 | 466 | 50 463 |
| No. of freeze‐all‐embryos | 37 116 | 19 728 | 58 454 | 1314 | 0 | 538 | 1228 | 118 378 |
| No. of cycles with pregnancy | 4648 | 1310 | 4487 | 89 | 4 | 0 | 103 | 10 641 |
| Pregnancy rate per ET | 22.8% | 25.9% | 18.7% | 16.8% | 16.0% | ‐ | 22.1% | 21.1% |
| Pregnancy rate per egg retrieval | 5.4% | 4.6% | 3.6% | 3.8% | 16.0% | ‐ | 2.8% | 4.3% |
| Pregnancy rate per egg retrieval excluding freeze‐all‐embryos | 9.5% | 15.3% | 6.6% | 8.7% | 16.0% | ‐ | 4.2% | 8.3% |
| SET cycles | 17 014 | 4449 | 19 292 | 340 | 2 | ‐ | 402 | 41 499 |
| Pregnancy following SET cycles | 3933 | 1176 | 3624 | 58 | 0 | ‐ | 92 | 8883 |
| Rate of SET cycles | 83.4% | 88.0% | 80.5% | 64.2% | 8.0% | ‐ | 86.3% | 82.2% |
| Pregnancy rate following SET cycles | 23.1% | 26.4% | 18.8% | 17.1% | 0.0% | ‐ | 22.9% | 21.4% |
| Miscarriages | 1161 | 273 | 1229 | 28 | 0 | ‐ | 20 | 2711 |
| Miscarriage rate per pregnancy | 25.0% | 20.8% | 27.4% | 31.5% | 0.0% | ‐ | 19.4% | 25.5% |
| Singleton pregnancies b | 4408 | 1256 | 4247 | 85 | 3 | ‐ | 98 | 10 097 |
| Multiple pregnancies b | 113 | 29 | 143 | 1 | 0 | ‐ | 3 | 289 |
| Twin pregnancies b | 109 | 29 | 142 | 1 | 0 | ‐ | 3 | 284 |
| Triplet pregnancies b | 4 | 0 | 1 | 0 | 0 | ‐ | 0 | 5 |
| Quadruplet pregnancies b | 0 | 0 | 0 | 0 | 0 | ‐ | 0 | 0 |
| Multiple pregnancy rate b | 2.5% | 2.3% | 3.6% | 1.2% | 0.0% | ‐ | 3.0% | 2.8% |
| Live births | 3246 | 965 | 3045 | 60 | 3 | ‐ | 78 | 7397 |
| Live birth rate per ET | 15.9% | 19.1% | 12.7% | 11.3% | 12.0% | ‐ | 16.7% | 14.7% |
| Total number of neonates | 3319 | 983 | 3150 | 61 | 3 | ‐ | 80 | 7596 |
| Singleton live births | 3164 | 947 | 2926 | 59 | 3 | ‐ | 76 | 7175 |
| Twin live births | 76 | 18 | 112 | 1 | 0 | ‐ | 2 | 209 |
| Triplet live births | 1 | 0 | 0 | 0 | 0 | ‐ | 0 | 1 |
| Quadruplet live births | 0 | 0 | 0 | 0 | 0 | ‐ | 0 | 0 |
| Pregnancy outcomes | ‐ | |||||||
| Ectopic pregnancies | 59 | 20 | 56 | 0 | 1 | ‐ | 1 | 137 |
| Heterotopic pregnancy | 0 | 0 | 0 | 0 | 0 | ‐ | 0 | 0 |
| Artificial abortions | 25 | 5 | 25 | 1 | 0 | ‐ | 1 | 57 |
| Still births | 18 | 4 | 5 | 0 | 0 | ‐ | 0 | 27 |
| Fetal reductions | 1 | 0 | 0 | 0 | 0 | ‐ | 0 | 1 |
| Unknown cycles for pregnancy outcomes | 104 | 32 | 121 | 0 | 0 | ‐ | 3 | 260 |
Abbreviations: ET, embryo transfer; GIFT, gamete intrafallopian transfer; ICSI, intracytoplasmic sperm injection; IVF–ET; in vitro fertilization‐embryo transfer; SET, single embryo transfer; TESE, testicular sperm extraction.
a
Others including zygote intrafallopian transfer (ZIFT).
b
Singleton, twin, triplet and quadruplet pregnancies were defined according to the numbers of gestational sacs in utero.