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. 2020 Mar 13;41(2):369–379. doi: 10.1177/0271678X20911469

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© The Author(s) 2020

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 4. — The SPM analysis results are overlaid onto the FA template. Colored voxels indicate T-scores showing increased k2 values of 1-C-11 acetate (a), and decreased FA values (b) in the MS group as compared to the NC group. Each image was anatomically normalized using the transformation matrix obtained by normalization of the coregistered T1-weighted 3 D MRI. FA images were smoothed for the analysis using a 10-mm FWHM isotropic Gaussian kernel for matching of the spatial resolution with the 1-C-11 acetate k2 images.