Figure 2.

Fucoidan inhibits NLRP3 inflammasome activity in ApoE-/- mice. (a) The plasma levels of IL-1β in ApoE-/- mice were measured by ELISA. (b, c) Representative western blot analysis of the protein expression levels of NLRP3, ASC, caspase-1, and IL-1β in right carotid arteries. All data are representative of three independent experiments. (d, e) Immunohistochemical analysis of NLRP3 in carotid atherosclerotic plaques. Scale bar = 50 μm. Data are presented as mean ± SE (n = 12). ^∗p < 0.05 vs. control; ^#p < 0.05 vs. model.