Table 1.
Inhibitory activity of GPI-anchored m36.4 in TZM-b1 cells against divergent HIV-1 subtypes
| HIV-1 | Subtype | Tropism | Mean % infection ± SD | |||
|---|---|---|---|---|---|---|
| GPI-FluIgG03 | GPI-m36.4 | Sec-FluIgG03 | Sec-m36.4 | |||
| Replication-competent virus | ||||||
| JR-CSF | B | CCR5 | 96 ± 3 | 0 | 128 ± 8 | 65 ± 5 |
| RHPA.c/2635 | B | CCR5 | 106 ± 7 | 0 | 120 ± 10 | 61 ± 4 |
| THRO.c/2626 | B | CCR5 | 92 ± 2 | 0 | 116 ± 4 | 53 ± 6 |
| CH077.t/2627 | B | CCR5 | 89 ± 3 | 0 | 108 ± 1 | 69 ± 4 |
| NL4-3 | B | CXCR4 | 85 ± 2 | 0 | 114 ± 5 | 43 ± 5 |
| LAI.2 | B | CXCR4 | 82 ± 3 | 0 | 120 ± 4 | 56 ± 5 |
| 89.6 | B | R5X4 | 90 ± 4 | 0 | 118 ± 6 | 59 ± 4 |
| MJ4 | C | CCR5 | 98 ± 5 | 0 | 112 ± 8 | 74 ± 3 |
| "Global Panel" pseudovirus | ||||||
| 398-F1_F6_20 | A | CCR5 | 141 ± 4 | 6 ± 1 | 102 ± 6 | 72 ± 4 |
| TRO.11 | B | CCR5 | 104 ± 1 | 0 | 113 ± 8 | 89 ± 5 |
| X2278_C2_B6 | B | CCR5 | 136 ± 8 | 0 | 106 ± 2 | 80 ± 3 |
| CE1176_A3 | C | CCR5 | 115 ± 1 | 0 | 101 ± 3 | 84 ± 4 |
| CE703010217_B6 | C | CCR5 | 112 ± 2 | 0 | 88 ± 3 | 75 ± 5 |
| HIV_25710-2.43 | C | CCR5 | 117 ± 2 | 0 | 106 ± 6 | 80 ± 4 |
| X1632-S2-B10 | G | CCR5 | 108 ± 0 | 3 ± 1 | 106 ± 2 | 82 ± 3 |
| 246_F3_C10_2 | A/C | CCR5 | 113 ± 2 | 0 | 105 ± 4 | 87 ± 4 |
| CNE8 | A/E | CCR5 | 139 ± 2 | 3 | 107 ± 5 | 93 ± 2 |
| CNE55 | A/E | CCR5 | 126 ± 2 | 1 | 103 ± 6 | 90 ± 6 |
| CH119.10 | B/C | CCR5 | 112 ± 2 | 0 | 111 ± 8 | 98 ± 7 |
| BJOX002000.03 | B/C | CCR5 | 106 ± 2 | 0 | 103 ± 5 | 93 ± 5 |
| VSV-G | NA | NA | 97 ± 1 | 103 ± 2 | 102 ± 7 | 111 ± 7 |
*The assay was performed in triplicate and repeated three times. Data are expressed as the means ± SD