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. 2021 Jan 18;21:43. doi: 10.1186/s12886-020-01797-z

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Representative optical coherence tomography (OCT) and corresponding fundus photography of RP patients with macular abnormalities. a An OCT image with cystic-appearing spaces in the left eye. b Fundus photograph of the left eye in picture a, showing bone spicule pigmentation in the mid-periphery and vessels attenuation. c OCT scan showed a homogenous layer of moderately reflective material, present on the inner retinal layer. d Fundus photography of the right eye in picture c, showed marked bone spicule pigmentation in the mid-periphery, waxy pallor of the optic disc and attenuated vessels. e OCT scan with lamellar macular hole. f: Fundus photography of the picture e, revealed bone spicule pigmentation in the mid-periphery and vessels attenuation. g OCT scan showed vitreomacular traction. h Fundus photography of the right eye in picture g, showed marked bone spicule pigmentation in the mid-periphery, waxy pallor of the optic disc and attenuated vessels. i OCT image showed disruption of the Bruch membrane/retinal pigment epithelium complex, accompanied by a hyper-reflective lesion connected with the subretinal pigment epithelium. j Fundus photography of the left eye in picture i, showed hemorrhage located in the inferior-temporal macular area