Scheme 1. Synthesis of PROTAC 1.
Reagents and conditions: (a) Ethyl bromoacetate, K2CO3, THF, 100 °C, 8 h; (b) aq. NaOH, EtOH, rt, overnight, 38% from 2; (c) HATU, N,N-diisopropylethylamine, DMF, rt, overnight, 48%.
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