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Compound 9 significantly inhibited the growth of MYD88 L265P mutant cell lines and inhibited the signaling molecules downstream of IRAK4 in a concentration-dependent manner. (a, b) Western blotting analysis of signaling molecules downstream of IRAK4 treated with compound 9 in (a) OCI-LY10 and (b) TMD8 cells. (c, d) Antiproliferative activity of compound 9 in (c) OCI-LY10 and (d) TMD8 cells. Data are shown as mean ± SD.
