Electron transfer pathway and the cofactor coordination in the Tma EtfABCX complex. (A) Cartoon representation of one Tma EtfABCX tetramer structure, with each subunit colored differently as labeled. C-FAD, flavin of the quinone reducing subunit C. (B) Orientation and distance of the six bound cofactors. (C–F) Enlarged views of the binding pocket and coordinating residues of BF-FAD (C), ET-FAD (D), QR-FAD (E), and the [4Fe-4S] clusters (F).