. 2021 Jan 4;118(2):e2008815118. doi: 10.1073/pnas.2008815118

Table 2.

Effect of 6G318S in combination with known antifungals

Well position	Compounds	MIC-alone (µg/mL)^*	MIC-comb (µg/mL)^*	FIC index^*	Effect
F6	6G-318S	1.000	0.125	0.37	Synergistic
	AmB	0.578	0.144	0.37	Synergistic
D6	6G-318S	1.000	0.500	0.63	Additive
	5-FC	8.100	2.025	0.63	Additive
D6	6G-318S	1.000	0.500	1.00	Additive
	IZ	0.176	0.088	1.00	Additive
G3	6G-318S	1.000	0.063	2.04	Indifferent
	Vor	0.044	0.087	2.04	Indifferent

MIC and FIC index were calculated by checkerboard assay, as illustrated in SI Appendix, Fig. S3. FIC index value of ≤0.5 is considered as synergy, >0.5 to 1 is additive, >1 to 4 is indifferent.