Table 3. Univariate and multivariate Cox regression analyses genes signiture for patients with osteosarcoma in study cohort.

	Univariate		Multivariate
Characteristics	HR	p.value	HR	p.value
Gender (Female vs Male)	0.666 (0.317, 1.399)	0.283
Age (<18 vs ≥18)	0.909 (0.345, 2.393)	0.846
Recurrence (No vs Yes)	19.348 (4.589, 81.563)	<0.001	5.374 (1.183, 24.404)	0.029
Primary tumor site (Arm/Hand OR Pelvis vs Leg/Foot)	0.487 (0.168, 1.413)	0.185
Specific tumor site (Femur vs Tibia or others)	0.642 (0.309, 1.337)	0.236
riskscore	13.915 (7.067, 27.398)	<0.001	9.869 (4.663, 20.887)	<0.001