Table 5. The lethal drug concentration that reduced parasite viability in 50% (IC50), lethal drug concentration that reduced WI-26VA4 cells viability in 50% (LD50), and selectivity index (SI) values obtained from in vitro tests with venom fractions from R. marina venom, and chloroquine (CQ) against P. falciparum W2 strain.
| Compounds | IC50 ± SD (μM)* | LD50 a ± SD (μM)* | SIa |
|---|---|---|---|
| Dehydrobufotenine | 19.11 ± 0.20 | 235.76 ± 4.03 | 12.33 |
| Marinobufotoxin | 5.31 ± 0.25 | 8.89 ± 2.66 | 1.67 |
| Marinobufagin | 3.89 ± 0.42 | 3.04 ± 0.25 | 0.78 |
| Bufalin | 3.44 ± 0.43 | 25.9 ± 7.04 | 7.52 |
| Chloroquine (CQ) | 1.04 ± 0.21 | >100 | >100 |
aLD50 and SI values were obtained with MTT cytotoxic test in human pulmonary fibroblast cells (WI-26VA4).
*Mean and standard deviation (SD) of triplicate experiments.