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. 2020 Dec 3;3(1):vdaa165. doi: 10.1093/noajnl/vdaa165

Figure 2.

Figure 2.

Broader antitumor activity of ST-401 in PD-glioma compared to glioma cell lines in culture. (A) ST-compounds inhibit the growth (TGI50) of 6 human glioma cell lines in the NCI-60 cell line panel. (B) ST-compounds reduce the viability of 4 PD-glioma isolates when measuring WST-1 cleavage. Results are mean ± SEM from 3 to 5 experiments. (C) ST-401 reduces the viability of T98G and MGG8 cells with comparable IC50s when measuring WST-1 cleavage. (D) NOC (3 μM) and MPS1-IN (30 μM) reduce the viability of T98G and MGG8 cells when measuring WST-1 cleavage. (E) ST-401 reduces the number of MGG8 cell in S phase when measuring BrdU-incorporation. Lack of response in T98G. (F) NOC (3 μM) and MPS1-IN (30 μM) reduce the number of MGG8 cell in S phase when measuring BrdU-incorporation. Lack of response in T98G and cells. (C–F) Results are mean ± SEM from n = 3–6 experiments. Two-way ANOVA analysis followed by Tuckey's post-test indicated significance of *P < .05, **P < .01 and ***P < .001 compared to vehicle control (dotted line).