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. 2020 Dec 3;3(1):vdaa165. doi: 10.1093/noajnl/vdaa165

Figure 5.

Figure 5.

ST-401 enhances the therapeutic efficacy of RT and TMZ in a PDGFB-glioma mouse model. (A) Survival of PDGFB-glioma mice treated with vehicle control (CTR, formulation only, white symbol), ST-401 (bidaily, 5 days/week for 4 weeks, black symbol), TMZ (50 mg/kg, once per day, 5 days/week for 4 weeks, light red symbol), TMZ + ST-401 (dark red symbol), RT (10-Gy, once, light blue symbol) and RT+ST-401 (dark blue symbol). Results are mean ± MEM of 10 mice per arm. Mantel Cox Test analysis indicated signifant difference of ***P < .001. (B–D) RT increases necrotic area in PDGFB-glioma as determined by histopathological analysis (B). Representative H&E stained sections of PDGFB-glioma in the CTR arm (C) and from the RT arm (D) illustrating the increase in necrotic area (asterixis) in the latter. Scale bar = 100 μm.