Table 2.
CMR Measures by HIV Status (n = 229)
| Mean (SD) or % (n) | ||||
|---|---|---|---|---|
| Characteristics | PWH (n = 134) | Uninfected (n = 95) | Adjusted Mean Difference or Odds Ratio (95% CI)a | P Valuea |
| Functional Characteristics | ||||
| LV ejection fraction, % | 59.3 (6.7) | 57.4 (7.1) | 2.0 (0.3–3.7) | .02 |
| LV ejection fraction, <50%b | 7% (10) | 11% (11) | 0.59 (0.24–1.49) | .26 |
| Global systolic circumferential strain, % | −21.9 (3.1) | −20.8 (5.5) | −1.1 (−2.2 to 0.0) | .05 |
| Peak diastolic circumferential strain rate, %s−1 | 1.36 (0.33) | 1.30 (0.30) | 0.07 (−0.01 to 0.15) | .09 |
| Myocardial Chamber Characteristics | ||||
| LV end diastolic volume, mL | 138 (31) | 142 (25) | −3 (−11 to 4) | .35 |
| LV end systolic volume, mL | 56.9 (19.4) | 60.8 (17.3) | −4.3 (−8.7 to 0.2) | .06 |
| LA dilation | 30% (40) | 25% (24) | 1.24 (0.67–2.28) | .50 |
| LA area index, cm2/m2 | 12.8 (2.2) | 12.3 (1.7) | 0.54 (0.01–1.07) | .05 |
| LV hypertrophy | 10% (14) | 7% (7) | 1.36 (0.51–3.63) | .55 |
| LV mass index, g/m2 | 55.4 (13.2) | 55.0 (11.0) | −0.2 (−2.8 to 2.4) | .88 |
| LV mass/volume ratio | 0.72 (0.12) | 0.73 (0.12) | −0.02 (−0.05 to 0.01) | .28 |
| LV septal wall thickness, mm | 10.11 (1.94) | 9.88 (1.62) | −0.15 (−0.58 to 0.28) | .50 |
| LV anterior wall thickness, mm | 7.44 (1.52) | 7.53 (1.51) | 0.15 (−0.22 to 0.53) | .42 |
| LV lateral wall thickness, mm | 7.69 (1.73) | 7.52 (1.65) | −0.11 (−0.53 to 0.31) | .60 |
| LV anterior wall thickness, mm | 8.23 (1.68) | 8.05 (1.59) | −0.13 (−0.54 to 0.28) | .54 |
| Myocardial Tissue Characteristics | ||||
| LV LGE presence | 72% (93) | 72% (65) | 0.98 (0.54–1.80) | .95 |
| Native T1, ms | 1247 (44) | 1242 (40) | 6 (−5 to 16) | .29 |
| Native T2, ms | 39.2 (2.5) | 39.2 (2.4) | 0.0 (−0.7 to 0.6) | .92 |
| T1W imaging, signal intensity ratio | 0.90 (0.15) | 0.87 (0.13) | 0.04 (0.00–0.07) | .07 |
| T2W imaging, signal intensity ratio | 1.46 (0.24) | 1.44 (0.21) | 0.02 (−0.03 to 0.08) | .50 |
| Extracellular volume fraction, % | 30.4 (5.1) | 29.3 (2.7) | 1.2 (0.1–2.3) | .04 |
| Pericardial effusion | 13% (18) | 9% (9) | 1.56 (0.66–3.68) | .31 |
Abbreviations: CI, confidence interval; CMR, cardiac magnetic resonance; HIV, human immunodeficiency virus; LGE, late-gadolinium enhancement; LA, left atrial; LV, left ventricular; PWH, persons with HIV; SD, standard deviation.
aComputed via linear or logistic regression for continuous and dichotomous parameters, respectively, adjusted for age, sex, and diagnosis of hypertension.
bTwo participants (1 person with HIV and 1 uninfected) had a LV ejection fraction <40%.