Supplementary table 1.
Hematologic parameters characterization and levels of serum ferritin and serum iron among alpha thalassemia 3.7kb deletion in metropolitan region of manaus.
| Manaus | Iranduba | Manacapuru | Presidente Figueiredo | Itacoatiara | Coari | p-value | |
|---|---|---|---|---|---|---|---|
|
Wide type (αα/αα) (A) | |||||||
| RBC (×106/mm L) | 4.67 ± 0.48 | 4.35 ± 0.57 | 4.71 ± 0.61 | 4.71 ± 0.48 | 4.75 ± 0.57 | 4.43 ± 0.56 | <.001 |
| Hg (g/dL) | 13.95 ± 1.42 | 13.08 ± 1.43 | 13.63 ± 1.45 | 13.56 ± 1.48 | 13.79 ± 1.42 | 13.03 ± 1.62 | <.001 |
| Hct (%) | 42.41 ± 4.3 | 39.03 ± 4.41 | 41.03 ± 4.41 | 41.52 ± 4.21 | 40.75 ± 4.25 | 40.33 ± 4.96 | <.001 |
| MCV (fL) | 91.07 ± 4.53 | 90.11 ± 7.62 | 87.49 ± 6.28 | 88.39 ± 4.94 | 85.25 ± 4.89 | 91.26 ± 5.63 | <.001 |
| MCH | 29.97 ± 1.97 | 30.20 ± 2.32 | 29.11 ± 2.41 | 28.87 ± 2.10 | 28.83 ± 1.25 | 29.48 ± 1.93 | <.001 |
| MCHC (pg) | 32.90 ± 1.28 | 33.57 ± 1.64 | 33.28 ± 1.76 | 32.67 ± 1.68 | 33.87 ± 1.32 | 32.32 ± 1.39 | <.001 |
| RDW (%) | 13.20 ± 1.18 | 13.07 ± 0.78 | 13.67 ± 0.97 | 13.51 ± 0.71 | 14.04 ± 0.68 | 12.90 ± 0.87 | <.001 |
| Serum Iron (μg/dL) | 81.97 ± 4.38 | 93.77 ± 25.62 | 85.46 ± 25.74 | 83.32 ± 32.59 | 90.60 ± 32.61 | 96.20 ± 32.37 | <.001 |
| Ferritin (μg/dL) | 137.27 ± 52.69 | 110.16 ± 33.28 | 109.87 ± 31.31 | 94.92 ± 25.31 | 96.30 ± 26.66 | 112.09 ± 47.01 | <.001 |
|
Heterozygous (−α/αα) (B) | |||||||
| RBC (×106/mm L) | 4.46 ± 0.41 | 4.52 ± 0.44 | 5.03 ± 0.51 | 4.52 ± 0.62 | 4.98 ± 0.62 | 4.72 ± 0.88 | .017 |
| Hg (g/dL) | 12.17 ± 1.11 | 12.01 ± 1.50 | 13.77 ± 1.40 | 12.41 ± 1.52 | 13.49 ± 1.20 | 12.86 ± 3.38 | .002 |
| Hct (%) | 38.30 ± 2.72 | 35.29 ± 3.85 | 42.27 ± 5.78 | 38.70 ± 4.88 | 38.81 ± 3.76 | 38.09 ± 7.86 | .062 |
| MCV (fL) | 86.19 ± 5.77 | 78.31 ± 7.87 | 83.91 ± 4.94 | 86.09 ± 8.51 | 78.24 ± 5.29 | 80.60 ± 5.25 | <.001 |
| MCH | 27.36 ± 2.25 | 26.68 ± 3.29 | 27.40 ± 2.13 | 27.62 ± 2.59 | 27.19 ± 1.62 | 25.16 ± 2.20 | .049 |
| MCHC (pg) | 31.75 ± 1.67 | 34.02 ± 1.59 | 32.65 ± 1.32 | 32.16 ± 2.07 | 34.81 ± 1.53 | 31.20 ± 1.57 | <.001 |
| RDW (%) | 12.41 ± 1.14 | 12.64 ± 1.17 | 13.89 ± 0.51 | 13.67 ± 0.74 | 13.41 ± 0.76 | 12.51 ± 1.46 | <.001 |
| Serum Iron (μg/dL) | 76.88 ± 5.56 | 76.48 ± 31.54 | 87.0 ± 32.21 | 66.54 ± 36.12 | 81.78 ± 35.46 | 81.65 ± 46.95 | .647 |
| Serum Ferritin (μg/dL) | 101.81 ± 40.91 | 101.42 ± 45.05 | 104.56 ± 32.63 | 102.95 ± 41.58 | 97.18 ± 33.39 | 114.07 ± 60.70 | .656 |
|
Homozygous (−α/−α) (C) | |||||||
| RBC (×106/mm L) | 4.84 ± 0.45 | 5.23 ± 1.16 | 5.44 ± 0.20 | 5.19 ± 0.51 | 5.55 ± 1.03 | 4.96 ± 0.16 | .517 |
| Hg (g/dL) | 12.22 ± 1.96 | 10.62 ± 2.52 | 12.95 ± 1.04 | 12.91 ± 1.58 | 12.46 ± 1.91 | 10.49 ± 0.78 | .098 |
| Hct (%) | 38.44 ± 5.41 | 35.02 ± 5.35 | 40.72 ± 1.16 | 38.27 ± 4.19 | 37.26± 5.88 | 32.45 ± 1.96 | .196 |
| MCV (fL) | 79.17 ± 5.22 | 67.08 ± 6.11 | 75.21 ± 6.67 | 73.96 ± 5.54 | 67.74 ± 7.27 | 65.34 ± 3.83 | .006 |
| MCH | 25.17 ± 2.58 | 20.67 ± 4.28 | 23.92 ± 2.18 | 24.95 ± 2.85 | 22.68 ± 2.76 | 21.13 ± 1.66 | .050 |
| MCHC (pg) | 31.75 ± 1.39 | 30.67 ± 4.42 | 31.81 ± 0.63 | 33.72 ± 3.29 | 33.51 ± 1.48 | 32.31 ± 0.7 | .222 |
| RDW (%) | 11.25 ± 0.78 | 12.85 ± 0.69 | 12.99 ± 0.91 | 13.42 ± 0.84 | 13.70 ± 0.77 | 12.94 ± 1.22 | <.001 |
| Serum Iron (μg/dL) | 70.25 ± 5.41 | 53.22 ± 19.61 | 101.03 ± 16.84 | 94.37 ± 3.82 | 92.45 ± 39.74 | 79.98 ± 21.10 | .176 |
| Serum Ferritin (μg/dL) | 86.55 ± 49.20 | 96.21 ± 47.82 | 88.52 ± 35.47 | 101.69 ± 52.74 | 85.88 ± 24.20 | 81.59 ± 9.42 | .011 |
RBC: Red Blood Cell Count; Hb: Haemoglobin; Hct: Haematocrit; MCV: Mean Corpuscular Volume; MCH: Mean Corpuscular Hb; MCHC: Mean Corpuscular Hb Concentration; RDW: red blood cell distribution width; SD: standard deviation.