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. 2021 Jan 18;9(1):e001688. doi: 10.1136/jitc-2020-001688

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© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See http://creativecommons.org/licenses/by-nc/4.0/.

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Reduced MC38 tumor growth in cbl-b^–/– mice. cbl-b^+/+ and cbl-b^–/– mice (n=5) were subcutaneously injected with MC38-CEA cells. (A) Tumor volume. (B) Representative images of tumors. (C) Percentage of CD8⁺PD1⁺Tim3⁺ TILs. (D) Representative image showing percentage of CD8⁺PD1⁺Tim3⁺ TILs. (E) CD8⁺PD1⁺Tim3⁺ TILs were sorted and expression of IFN-γ, TNF-α and granzyme B was analyzed by real-time PCR. The data are representative of three independent experiments. Statistics are mean±SD, calculated by Student’s t-test (two-tailed). CEA, carcinoembryonic antigen; IFN-γ, intergeron gamma; TIL, tumor-infiltrating lymphocyte; TNF-α, tumor necrosis factor alpha.