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. 2021 Jan 17;9(1):e001895. doi: 10.1136/jitc-2020-001895

Figure 6.

Figure 6

IL-17A is elevated in MSS CRC and is associated with NRF1, miR-15b-5p, and PD-L1 expression in tumor tissues. (A) Two representative IHC or ISH staining results for IL-17A, miR-15b-5p, NRF1, and PD-L1 in tissues of patients with CRC (scale bar, 100 µm). (B) IL-17A positive cell count was positively correlated with NRF1 expression (p<0.001, R=0.355). (C) NRF1 expression was negatively correlated with miR-15b-5p expression (p<0.001, R=−0.4526). (D) miR-15b-5p expression was negatively correlated with PD-L1 expression (p<0.001, R=−0.4260). (E) IL-17A positive cells is elevated in tumors of MSS relative to MSI-H tumors (p<0.01). (F) miR-15b-5p expression is decreased in tumors of MSS relative to MSI-H tumors (p<0.01). (G) Correlations between IL-17A positive cells and CD3+ cells is in MSS CRC tissues (p=0.1079, R=0.235). (H) Correlations between IL-17A positive cells and CD33 positive cells is in MSS CRC tissues (p<0.001, R=0.2951). P values and R values were calculated based on the analysis of Pearson’s correlation. Student’s t test. *P<0.05, **p<0.01, and ***p<0.001. CRC, colorectal cancer; IHC, immunohistochemical staining; ISH, in situ hybridization; IL, interleukin; MSI-H, microsatellite instability-high; MSS, microsatellite stable; NRF1, nuclear respiratory factor 1; PD-L1, programmed cell death ligand 1.