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. 2021 Jan 14;13:379–392. doi: 10.2147/CMAR.S287676

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© 2021 Cheng et al.

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The UBA6-AS1 silencing-induced effects on GBM cells were weakened following HOXA2 upregulation. (A) Western blotting was employed to measure HOXA2 protein expression in pcDNA3.1-HOXA2-transfected or si-NC-transfected U251 and T98 cells. (B, C) Cell Counting Kit-8 assay and flow cytometric analysis were used to evaluate the proliferation and apoptosis of U251 and T98 cells following co-transfection with pcDNA3.1-HOXA2 or pcDNA3.1 and si-UBA6-AS1. (D) Changes in the migration and invasion of U251 and T98 cells following transfection with pcDNA3.1-HOXA2 or pcDNA3.1 in combination with si-UBA6-AS1. **P < 0.01.

Abbreviations: GBM, glioblastoma; HOXA2, homeobox A2; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; UBA6-AS1, UBA6 antisense RNA 1; si-NC, negative control small interfering RNA; si-UBA6-AS1, small interfering RNA targeting UBA6-AS1.