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. 2021 Jan 14;13:367–377. doi: 10.2147/CMAR.S277399

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© 2021 Cheng et al.

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UCA1 and CYP1B1 bind to miR-513a-3p in human gastric cancer cell. (A) Wild-type (WT) or mutant (MUT) sequence of UCA1 and CYP1B1 bound to miR-513a-3p; B-C, WT or MUT sequence of UCA1 (B) and CYP1B1 (C) bound to miR-513a-3p were cotransferred into AGS cells with miR-513a-3p-NC (NC), miR-513a-3p-mimic (mimic) or miR-513a-3p-inhibitor (inhibitor), and then measured the luciferase activity; (D), UCA1 knockdown increased the expression of miR-513a-3p in AGS and NCI-N87 cells; (E) immunoblotting was used to detected the expression of CYP1B1 protein in human gastric cancer cells; (F) schematic diagram of UCA1 promoting the expression of CYP1B1 by binding to miR-513a-3p. Each experiment was repeated three times independently. The relative luciferase activity was shown as mean ±SD, *p<0.001 vs NC group and **p<0.001 and the p-value was calculated by post hoc comparisons in (B and C) and by Student’s t-test in (D).