Table 3. Gene ontology enrichment analysis for those proteins that showed reduced abundance when ERK1/2 activity was blocked.

Gene name	Protein name
Top enriched GO term — immune response GO:0006955
lfn-γ	Interferon-gamma
II2rα	Interleukin 2 receptor, alpha chain
II2	Interleukin 2
Ltα	Lymphotoxin alpha
Nfil3	Nuclear factor, interleukin 3 regulated
Serpinb9	Serine (or cysteine) peptidase inhibitor, clade B, member 9
Tnfsf11	Tumor necrosis factor (ligand) superfamily, member 11
Tnfsf8	Tumor necrosis factor (ligand) superfamily, member 8
Tnfrsf18	Tumor necrosis factor receptor superfamily, member 18
Tnfrsf4	Tumor necrosis factor receptor superfamily, member 4
Tnf	Tumor necrosis factor

Proteins that showed the greatest drop in abundance (P-value < 0.05 and fold change >2 standard deviations from the mean fold change; two-tailed t-test with unequal variance) or a presence/absence expression profile, were subject to enrichment analysis for biological processes. The top enriched process is presented ‘immune response’ GO:0006955, along with a list of those proteins identified within this enrichment group.