Fig. 3.

ORF8 Mutations at conserved amino acids between 8 viral species.

Protein sequence of SARS-CoV-2 ORF8 (YP_009724396.1), β-strands and disulfide bridges are indicated below the protein sequence (Flower et al., 2020). 59 mutations that were found at conserved amino acids between 8 viral species are indicated above. Mutations at Cysteines 25, 37, 83, 90 and 102 that form disulfide bridges are indicated in red. No mutation was found at C61. Some variants were found at conserved amino acids and were located in β-strands like Q23X(H), C25F(S), P30S (L,Q,T), W45S(L,C,X), R48G, I88T (F,V), C90F, G96V(S,C), R101(L,C) and C102F(Y), D113Y, V116A, V117F and L118X(V,S,F). Red squares indicate deleterious mutations. (For interpretation of the references to colour in this figure legend, the reader is referred to the web version of this article.)