Skip to main content
. Author manuscript; available in PMC: 2021 Sep 1.
Published in final edited form as: Arthritis Rheumatol. 2020 Aug 9;72(9):1514–1523. doi: 10.1002/art.41284

Figure 3. FOXO1 occupies active regulatory regions.

Figure 3.

A) Chow-Ruskey plot showing FoxO1 occupancy overlapping with histone marks of active regulatory regions in human chondrocytes. The area of each region is proportional to the number of FOXO1 peaks overlapping with each histone mark combination. Each region is color-coded according to the number of histone marks overlapping with FOXO1 peaks: FOXO1 peaks overlapping with all four active histone marks (red), three histone marks (dark orange), two histone marks (light orange) and with only one histone mark (yellow). Histone marks are also color-coded: H3K9ac (green), H3K27ac (red), H3K4me1 (blue) and H3K4me3 (purple).

B) Enrichment of FOXO1 binding to predicted RefSeq genomic elements and chondrocyte enhancers identified using chondrocyte-derived histone marks for poised (H3K4me1) and active (H3K4me1+H3K27ac) enhancers. 3UTR: 3’ untranslated region; miRNA: micro RNA; ncRNA: non-coding RNA; TTS: transcription termination site; pseudo: pseudogene; Non-cod/non-enhan: non-coding regions which are not enhancers; 5UTR: 5’ untranslated region; snoRNA: small nucleolar RNA; snRNA: small nuclear RNA.