Table 1.

Over-represented pathways in Reactome DB of FOXO1 bound genes differentially expressed in OA. All 2985 FOXO1 bound genes were used as background.

Terms in Reactome DB	Enrichment	logP	Genes in Term	Target Genes in Term	Total Target Genes	Total Genes	Gene Symbols
Interleukin-4 and 13 signaling	4.91E-07	−14.53	37	18	236	1647	TNFRSF1B, JUNB, F13A1, BCL6, MMP2, COL1A2, S1PR1, RORC, PIM1, IRF4, CDKN1A, VCAM1, CCND1, FOS, IL6R, MYC, SOCS3, RHOU
Extracellular matrix organization	2.33E-06	−12.97	77	27	236	1647	COL6A3, SPP1, COL15A1, MMP2, COL1A2, COA1, ITGB3, VCAM1, SPARC, LTBP1, COL5A2, COL13A1, NCAM1, COL25A1, FBLN1, ITGB4, LUM, ADAMTS5, COL2A1, EFEMP1, ITGB8, HAPLN1, TNC, ASPN, HTRA1, P4HA3, ITGB5
Collagen chain trimerization	1.07E-04	−9.14	13	8	236	1647	COL5A2, COL13A1, COL25A1, COL15A1, COL6A3, COL1A2, COL2A1, COL3A1
Collagen biosynthesis and modifying enzymes	3.29E-04	−8.02	18	9	236	1647	COL13A1, COL5A2, COL25A1, P4HA3, COL1A2, COL6A3, COL15A1, COL3A1, COL2A1
Collagen formation	4.03E-04	−7.82	22	10	236	1647	COL5A2, COL13A1, P4HA3, COL25A1, COL15A1, ITGB4, COL6A3, COL1A2, COL2A1, COL3A1
Class B/2 (Secretin family receptors)	4.75E-04	−7.65	12	7	236	1647	WNT11, CD55, ADM, FZD8, WNT5A, FZD10, FZD5
Assembly of collagen fibrils and other multimeric structures	9.05E-04	−7.01	13	7	236	1647	COL3A1, COL2A1, COL1A2, COL6A3, COL5A2, ITGB4, COL15A1
GPCR ligand binding	9.38E-04	−6.97	28	11	236	1647	CCL28, CD55, FZD8, WNT5A, ADM, WNT11, AVPR1A, FZD5, FZD10, PENK, S1PR1
Senescence-Associated Secretory Phenotype (SASP)	1.20E-03	−6.73	17	8	236	1647	CDK6, CDKN2B, CDKN1B, FOS, UBC, CDKN1A, IGFBP7, CEBPB
Circadian Clock	1.83E-03	−6.30	30	11	236	1647	NPAS2, BHLHE40, ARNTL, BHLHE41, NFIL3, UBC, KLF15, NR1D1, SREBF1, PER1, SIK1