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. 2020 Dec 23;9:e59073. doi: 10.7554/eLife.59073

Figure 7. Model of BRG1 and AP-1 driving epithelial cell signature in SCCOHT tumorigenesis.

Figure 7.

Following BRG1 reexpression in SCCOHT cells, BRG1 is recruited to and opens distal chromatin enriched in AP-1 motifs. BRG1 is also recruited to promoters of epithelial genes that have AP-1 motifs. These epithelial genes are upregulated in the presence of both BRG1 and AP-1 at the gene and protein level.