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. 2020 Oct 22;42(2):192–201. doi: 10.1093/eurheartj/ehaa791

Figure 2.

Figure 2

Functional improvement in a large animal model of chronic HF. (A) Left ventricular ejection fraction over time for different treatment regimens with CDR132L. (B) Functional improvement indicated by ejection fraction change from month 1 to month 6 (delta ejection fraction; in absolute per cent points). (C) Responder analysis for different treatment regimens (values presented are corrected with the ejection fraction change in the placebo group). (D) End-systolic volume over time. (E) Changes in end-systolic volume from month 1 to month 6 (delta end-systolic volume). (F) Left atrial volume over time. (G) Changes in left atrial volume from month 1 to month 6 (delta left atrial volume). Data are mean ± SD; P-values: two-tailed Mann–Whitney U test (Placebo vs. treatment regimen). EF, ejection fraction; ESV, end-systolic volume; LAV, left atrial volume; LV, left ventricular.