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. 2021 Jan 5;11:584116. doi: 10.3389/fimmu.2020.584116

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Copyright © 2021 Wright, Lyon, Chapman, Moots and Edwards

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Transcriptomic analysis of genes differently expressed (1.5-fold change) between peripheral blood (PB) and synovial fluid (SF) neutrophils. (A) IPA signaling pathways predicted to be up-regulated (red) or down-regulated (green) in SF neutrophils. (B) Heatmap showing chemokine gene expression in PB and SF neutrophils. (C) Leukocyte extravasation pathway (p=1.41x10^-7) showing genes up-regulated (red) or down-regulated (green) in SF neutrophils (white = not expressed).