Table 3.
Aggregated medical costs associated with managing AEs of interest for intravenous iron preparations reported in the USA from 1 January 2014 to 31 December, 2019
| Death costs | Hospital costs | Non-death, hospital costs (ER visit) | Total costs | Total AEs | Average costs/AE | Total patients | Average costs/patient | |
|---|---|---|---|---|---|---|---|---|
| Hypersensitivity reactions: including anaphylaxis/anaphylactic shock | ||||||||
| Iron dextran | $155,929 | $164,983 | $101,225 | $422,137 | 49 | $8,615 | 695,827 | $0.61 |
| Iron sucrose | $62,989 | $372,437 | $289,119 | $724,544 | 172 | $4,212 | 4,268,967 | $0.17 |
| Ferumoxytol | $425,749 | $403,298 | $411,915 | $1,240,963 | 152 | $8,164 | 1,004,275 | $1.24 |
| Ferric carboxymaltose | $33,528 | $126,562 | $490,341 | $650,431 | 355 | $1,832 | 1,183,784 | $0.55 |
| Hypersensitivity reactions: excluding anaphylaxis/anaphylactic shock | ||||||||
| Iron dextran | $124,845 | $66,612 | $46,773 | $238,230 | 27 | $8,823 | 695,827 | $0.34 |
| Iron sucrose | $0 | $206,484 | $172,835 | $379,319 | 130 | $2,918 | 4,268,967 | $0.09 |
| Ferumoxytol | $148,630 | $193,090 | $226,319 | $568,038 | 84 | $6,762 | 1,004,275 | $0.57 |
| Ferric carboxymaltose | $33,528 | $68,891 | $266,596 | $369,015 | 304 | $1,214 | 1,183,784 | $0.31 |
| Anaphylaxis/anaphylactic shock | ||||||||
| Iron dextran | $31,084 | $98,371 | $54,453 | $183,907 | 22 | $8,359 | 695,827 | $0.26 |
| Iron sucrose | $62,989 | $165,952 | $116,283 | $345,225 | 42 | $8,220 | 4,268,967 | $0.08 |
| Ferumoxytol | $277,120 | $210,208 | $185,597 | $672,925 | 68 | $9,896 | 1,004,275 | $0.67 |
| Ferric carboxymaltose | $0 | $57,671 | $223,745 | $281,416 | 51 | $5,518 | 1,183,784 | $0.24 |
AE adverse event, ER emergency room
All monetary values are US$
All costs were inflation adjusted on a yearly basis using the medical care services component of the consumer price index (not seasonally adjusted) for each month of December