Table 2.
Univariable and multivariable prediction analysis of locoregional recurrence-free survival
| n = 70 patient parameters | Local control | Recurrence | Univariable* | Multivariable** | ||
|---|---|---|---|---|---|---|
| Mean ± SD | Mean ± SD | p value* | p value | HR (95%CI) | ||
| Clinical parameters | Gender | 0.7 ± 0.5 | 0.6 ± 0.5 | 0.665 | – | |
| Age | 62.6 ± 7.9 | 65.1 ± 6.2 | 0.167 | – | ||
| T-stage | 3.0 ± 0.9 | 3.1 ± 0.9 | 0.929 | – | ||
| N-stage | 1.4 ± 0.8 | 1.8 ± 0.4 | 0.695 | – | ||
| HPV | 0.4 ± 0.5 | 0.2 ± 0.4 | 0.036 | 0.036 | 0.26 (0.08–0.91) | |
| Location PT | 1.2 ± 0.4 | 1.2 ± 0.44 | 0.543 | – | ||
| Smoking (PY) | 22.8 ± 18.7 | 30.1 ± 17.3 | 0.101 | – | ||
| Alcohol (≥ 3drinks/day) | 0.43 ± 0.5 | 0.7 ± 0.5 | 0.054 | – | ||
| Intoxications | ||||||
| None | 0.9 ± 0.8 | 1.4 ± 0.8 | 0.054 | – | ||
| Smoking or alcohol use | – | – | 0.525 | – | ||
| Smoking and alcohol use | – | – | 0.031 | – | ||
| Primary tumors | ||||||
| DWI | ADCGTV (cm3) | 0.8 ± 0.7 | 1.2 ± 1.4 | 0.023 | 0.021 | 1.69 (1.08–2.64) |
| ADC (× 103 mm2/s) | 1.2 ± 0.2 | 1.2 ± 0.2 | 0.166 | – | ||
| IVIM | D* (× 102 mm2/s) | 0.18 ± 0.1 | 0.18 ± 0.06 | 0.535 | – | |
| D (mm2/s) | 0.96 ± 0.2 | 1.0 ± 0.2 | 0.373 | – | ||
| F (× 102 mm2/s) | 1.4 ± 0.5 | 1.3 ± 0.6 | 0.342 | – | ||
| DCE | DCEGTV (cm3) | 11.6 ± 7.8 | 16.1 ± 14.6 | 0.047 | 0.016 | 1.06 (1.01–1.10) |
| Kep (min−1) | 1.1 ± 0.4 | 1.2 ± 0.6 | 0.138 | – | ||
| Ktrans (min−1) | 0.6 ± 0.3 | 0.74 ± 0.3 | 0.027 | 0.01 | 8.50 (1.68–43.1) | |
| Ve | 1.2 ± 0.8 | 2.0 ± 1.6 | 0.008 | 0.015 | 1.64 (1.10–2.43) | |
| 18F-FDG-PET | MATV (cm3) | 9.7 ± 7.6 | 13.7 ± 16.5 | 0.066 | 0.048 | 1.04 (1.00–1.09) |
| SUVmax (Bq) | 8.3 ± 3.9 | 8.7 ± 5.9 | 0.158 | – | ||
| SUVmean (Bq) | 6.0 ± 2.4 | 6.5 ± 3.8 | 0.193 | – | ||
| SUVpeak (Bq) | 7.3 ± 3.2 | 8.1 ± 5.1 | 0.133 | – | ||
| TLG (Bq × cm3) | 66.2 ± 70.3 | 93.2 ± 104.3 | 0.039 | – | ||
| Lymph node metastases | ||||||
| DWI | ADCGTV (103 cm3) | 5.9 ± 4.9 | 6.1 ± 4.9 | 0.588 | – | |
| ADC (× 103 mm2/s) | 1.1 ± 0.24 | 1.2 ± 0.3 | 0.596 | – | ||
| IVIM | D* (mm2/s) | 2.6 ± 0.7 | 2.6 ± 0.7 | 0.914 | – | |
| D (mm2/s) | 0.78 ± 0.2 | 0.8 ± 0.2 | 0.485 | – | ||
| f (× 102 mm2/s) | 1.8 ± 0.6 | 1.76 ± 0.7 | 0.892 | – | ||
| DCE | DCEGTV (cm3) | 4.7 ± 3.5 | 6.4 ± 4.7 | 0.076 | 0.018 | 1.18 (1.03–1.36) |
| Kep (min−1) | 0.9 ± 0.6 | 1.1 ± 0.7 | 0.692 | – | ||
| Ktrans (min−1) | 1.2 ± 1.1 | 1.4 ± 1.4 | 0.764 | – | ||
| Ve | 1.3 ± 0.9 | 1.4 ± 1.5 | 0.653 | – | ||
| 18F-FDG-PET | MATV (cm3) | 6.2 ± 7.3 | 6.4 ± 5.7 | 0.452 | – | |
| SUVmax (Bq) | 8.0 ± 4.4 | 8.4 ± 3.1 | 0.554 | – | ||
| SUVmean (Bq) | 5.0 ± 2.4 | 5.4 ± 1.9 | 0.407 | – | ||
| SUVpeak (Bq) | 6.1 ± 3.3 | 6.6 ± 2.6 | 0.371 | – | ||
| TLG (Bq × cm3) | 7.6 ± 12.4 | 7.9 ± 10.3 | 0.354 | – | ||
*Univariable Cox regression analysis
**Multivariable Cox regression analysis
Univariable and multivariate Cox regression analysis for locoregional recurrence of primary tumor and lymph node metastasis imaging parameters, compared between responders and non-responders. In the multivariate analysis, all parameters per modality were combined, which lead to a loss of intoxications and TLG as remaining predictive parameters for locoregional recurrence