TABLE 2.

Pro-angiogenic factors involved in angiogenesis.

Factor	Abbreviation	Angiogenic function
Vascular endothelial growth factor	VEGF	Inducing angiogenesis by stimulating proliferation, survival, and migration of ECs
Basic fibroblast growth factor	bFGF	Inducing angiogenesis by stimulating proliferation and migration of ECs and extracellular matrix degradation
Hypoxia-inducible factor 1-alpha	HIF-1α	Regulating proangiogenic factor expression under oxygen depletion
Platelet-derived growth factor	PDGF	Inducing angiogenesis by stimulating proliferation, migration and tube formation of ECs and regulating VEGF signaling
Tryptase	TRYPT	Inducing angiogenesis by stimulating proliferation of ECs and vascular tube formation
Colony stimulating factor 1	CSF-1	Inducing release of proangiogenic factors by MDSC
Placental growth factor	PlGF	Inducing angiogenesis by stimulating proliferation, survival and migration of ECs and recruiting proangiogenic macrophages
Angiopoietin-2	Ang2	Regulating neovascular remodeling, vessel maturation and sensitizing ECs to cytokines
Matrix metalloproteases	MMPs	Remodeling of ECM for endothelial migration
6-Phosphofructo-2-Kinase/Fructose-2,6-Biphosphatase	PFKFB3	Metabolic regulation of proliferation and migration in ECs
MYC		Inducing angiogenesis in combination with HIF-1α and VEGF
Aldehyde dehydrogenase 18 family member A1	ALDH18A1	Regulating collagen biosynthesis for remodeling of ECM for endothelial migration
Squalene epoxidase	SQLE	Regulating cholesterol biosynthesis for EC proliferation
Apelin	APLN	Involved in developmental angiogenesis and expressed in angiogenic ECs
miR-23a		Inducing angiogenesis via HIF-1α signaling
Fibronectin/EIIIB		Remodeling of ECM for endothelial migration