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. 2021 Jan 5;10:609940. doi: 10.3389/fonc.2020.609940

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Copyright © 2021 Huang, Huang, Chen, Ni, Huang, Huang and Ge

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Multiple verifications of IL18BP expression in STAD. (A) STAD (n = 408) and normal (n = 211) tissues from the GEPIA database verified that IL18BP was significantly upregulated in STAD (p < 0.05). (B) A total of 30 fresh STAD and paired normal tissues were collected from Tongji Hospital, Shanghai, China. IL18BP was significantly upregulated in STAD tissues (p < 0.05), as shown in qPCR analysis. (C) IL18BP expression was significantly upregulated in STAD samples at the protein level, as shown by IHC (n = 12 per group). (D) IL18BP was a prognostic risk factor in patients with STAD (p = 0.003) according to the Kaplan-Meier analysis of GSE15459 from GEO database. (E) IL18BP was a prognostic risk factor in patients with STAD (log rank P =1e-06) from KMPLOT database.