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. 2021 Jan 5;10:609940. doi: 10.3389/fonc.2020.609940

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Copyright © 2021 Huang, Huang, Chen, Ni, Huang, Huang and Ge

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CD4+ T cells are a prognostic predicting marker in STAD. (A) Violin plot of the relative fraction of tumor-infiltrating immune cells, estimated by CIBERSORT in patients with STAD from TCGA database. (B) LASSO regression was performed to prevent the bias of overfitting. (C) Reduced multi-cox regression model based on the original cox regression model and LASSO regression. Activated CD4+ memory T cells (p = 0.002), Macrophage M0 (p = 0.126), and regulatory T cells (p=0.049) were identified to be potential markers predicting the prognosis of STAD. (D) Nomogram was constructed based on the reduced multi-cox regression model (C-index = 0.6). (E) The calibration curves of 3-year-survival (blue) and 5-year-survival (red) indicated the acceptable accuracy.