Skip to main content
. 2021 Jan 18;12:428. doi: 10.1038/s41467-020-20481-w

Fig. 2. Mode of interaction of SRSF1 RRM1 with a CA dinucleotide.

Fig. 2

A Overlay of the 20 lowest-energy structures superimposed on the backbone of the structured parts of the protein and heavy atoms of RNA. The protein backbone is shown in gray and heavy atoms are shown in orange (P atoms), yellow (C atoms of RNA), red (O atoms), and blue (N atoms). The RRM (residues 1–89) and the ordered region of RNA (C3 and A4) are shown. B The solution structure of the complex is shown in ribbon (protein backbone) and stick (RNA) representation. Protein side chains or backbone involved in RNA interactions are shown as sticks. C atoms of the protein are in green and H bonds in magenta. C Snapshot of protein–RNA interactions observed during MD simulations performed with the complex formed by SRSF1 RRM1 and the AACAAA RNA. The blue sphere corresponds to a water molecule. D Snapshot of protein–RNA interactions observed during MD simulations performed with the complex formed by SRSF1 RRM1 and the AACGAA RNA.