Fig. 1.

Domain architecture of BET family proteins in human (h), mouse (m), Drosophila (d), and yeast (y). Numbers indicate the amino acid boundaries of each domain in individual proteins. Alignment of amino acid sequences was based on published information using the following accession numbers retrieved from GenBank databases: hBRD2, NM_005104; hBRD3, NM_007371.4; hBRD4-L, NM_058243; hBRD4-S, NM_014299; hBRDT, NM_001242805; mBRD2, NM_010238; mBRD3, NM_001113574; mBRD4-L, NM_020508; mBRD4-S, NM_198094; mBRDT, NM_014299; dfs(1)h, NM_078523; yBdf1, NM_001182287; yBdf2, AJV11655. Abbreviations: BD1, the first bromodomain; BD2, the second bromodomain; Bdf1, chromatin-binding protein BDF1; BRD, bromodomain protein (numbers 2–4); CTD, C-terminal domain; ET, extraterminal domain; Fs(1)h, female sterile (1) homeotic