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. 2021 Jan 19;6:23. doi: 10.1038/s41392-020-00384-4

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — The role of BETs in regulating the expression of immune genes mediated by transcription factors. Abbreviations: ACOD1, aconitate decarboxylase 1; AIRE, autoimmune regulator; ALOX12, arachidonate 12-lipoxygenase, 12 S type; BATF, basic leucine zipper ATF-like transcription factor; CCL, C-C motif chemokine ligand (numbers 2–12); CCN2, cellular communication network factor 2; CD, CD molecule (numbers 4–274); CD40LG, CD40 ligand; CDX2, caudal-type homeobox 2; CEBPA, CCAAT enhancer binding protein alpha; CELF2, CUGBP Elav-like family member 2; CMPK2, cytidine/uridine monophosphate kinase 2; CSF1, colony stimulating factor (numbers 1–3); CXCL9, C-X-C motif chemokine ligand 9; E2F1, E2F transcription factor 1; EGR2, early growth response 2; ESM1, endothelial cell-specific molecule 1; ETS1, ETS proto-oncogene 1; FGF2, fibroblast growth factor 2; FLT1, fms-related receptor tyrosine kinase 1; FOXL1, forkhead box L1; FOXM1, forkhead box M1; FOXO3, forkhead box O3; FOXP1, forkhead box P1; FST, follistatin; ICAM1, intercellular adhesion molecule 1; ICOS, inducible T-cell costimulatory; IFIT2, interferon-induced protein with tetratricopeptide repeats 2; IFNB1, interferon beta 1; IL1B, interleukin 1 beta; IL, interleukin (numbers 4–22, including “A” variants); INS, insulin; IRF, interferon regulatory factor; JUN, Jun proto-oncogene, AP-1 transcription factor subunit; KRT13, keratin 13; LIN54, lin-54 DREAM MuvB core complex component; MX1, MX dynamin-like GTPase 1; MYC, MYC proto-oncogene, bHLH transcription factor; NECTIN2, nectin cell adhesion molecule 2; NLRP3, NLR family pyrin domain containing 3; NPPB, natriuretic peptide B; PLK1, polo-like kinase 1; PPARG, peroxisome proliferator activated receptor gamma; PTHLH, parathyroid hormone-like hormone; PVR, PVR cell adhesion molecule; RBPJ, recombination signal binding protein for immunoglobulin kappa J region; RELA, RELA proto-oncogene, NF-κB subunit; RORC, RAR-related orphan receptor C; RUNX2, RUNX family transcription factor 2; S100A9, S100 calcium-binding protein A9; SLPI, secretory leukocyte peptidase inhibitor; SP7, Sp7 transcription factor; SPRY2, sprouty RTK signaling antagonist 2; STAT, signal transducer and activator of transcription; TGIF1, TGFB-induced factor homeobox 1; TNF, tumor necrosis factor; TP53, tumor protein p53; ULBP1, UL16 binding protein (numbers 1–3)