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Efficient recovery of endogenous neurogenic Cre driver lines by 2A-Cre-γcry:EGFP targeted integration.
| Neurogenic gene | ascl1b | olig2 | neurod1 |
|---|---|---|---|
| Targeted exon | 1 | 2 | 2 |
| 5′ and 3′ homology arms (bp/bp) | 48/48 | 48/48 | 48/48 |
| F0 embryos expressing secondary marker | 58% (61/105) | 48% (52/109) | 37% (21/57) |
| F0 adults transmitting secondary marker | 100% (3/3) | 10% (2/20) | 20% (1/5) |
| F0 adults transmitting precise integration allele | 33% (1/3) | 5% (1/20) | 20% (1/5) |
