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. 2021 Jan 5;11:601057. doi: 10.3389/fphys.2020.601057

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Copyright © 2021 Boncompagni, Pecorai, Michelucci, Pietrangelo and Protasi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Representative EM images and corresponding cartoons showing SR linkers. SR vesicles in adult control mice [(A), and relative cartoon in panel (B)], SR stacks in adult exercised mice [(C), and relative cartoon in panel (D)], and TA tubes in aged EDL muscle fibers [(E), and relative cartoon in panel (F)]. SR linkers are pointed by empty arrows in EM images and represented as red rods in the cartoons. Image and numeric data in panels (B,D) originates from adult mice acutely exercised in Boncompagni et al. (2017). Data are shown as mean ± SEM; *p < 0.01 (adult vs. adult exercised). Scale bar: (A,C,E), 0.1 μm; inset, 0.05 μm.