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Diagrammatic illustration of the experimental protocol. White bars indicate normal 12-h light:dark cycling with lights on at 0600 MDT or 0700 h MST, black bars indicate light cycle reversal periods for the chronic disruption of rhythms (CDR) group. CDR, chronic disruption of rhythms; MDT, Mountain Daylight Time; MST, Mountain Standard Time; M. vaccae, Mycobacterium vaccae NCTC 11659; NLD, normal light:dark condition; Vehicle, borate-buffered saline vehicle; ZT, Zeitgeber time.
