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. 2021 Jan 5;10:615534. doi: 10.3389/fonc.2020.615534

Figure 3.

Figure 3

2C8 enables phagocytosis of tumor cells in vitro. (A) Representative images of human macrophages (red) phagocytosing Raji cells (green) following treatment with the 10 μg/ml indicated antibodies or not. Scale bar, 50 μm. (B) Representative images of mouse macrophages (red) phagocytosing Raji cells (green) following treatment with the 10 μg/ml indicated antibodies or not. Scale bar, 50 μm. (C) Mouse macrophages phagocytose Raji cells in the presence of 2C8 or B6H12.2 in a concentration-dependent manner. (D) Bar graph demonstrating the change of phagocytosis rates by mouse M0, M1, and M2 macrophages toward Raji cells in the presence of 10 μg/ml 2C8 or 10 μg/ml B6H12.2. (E) In vitro phagocytosis of multiple tumor cells by mouse macrophages in the presence of 10 μg/ml 2C8 or 10 μg/ml B6H12.2. The data are represented as mean ± SEM. (****p < 0.0001; ***p < 0.001; **p < 0.01; *p < 0.05, multiple t tests). The experiment was performed three times with similar results.