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. 2021 Jan 5;10:615534. doi: 10.3389/fonc.2020.615534

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Copyright © 2021 Lin, Xiong, Hao, Song, Liu, Yang, Yuan, Fan, Zhang, Hao, Ye, Lu, Zhang, Wang and Xiong

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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2C8 inhibits tumor growth in xenotransplantation models. (A) Raji xenografted mice treated with two different doses of 2C8 or PBS (n=7). The tumor volume of Raji tumors per group (n=7) is depicted over time. (B) Raji xenografted mouse survival after two different doses of 2C8 or PBS treatment (n = 7). (C) BJAB xenografted mice treated with 200 μg 2C8 or PBS (n=4). The tumor volume of BJAB tumors per group (n=4) is depicted over time. (D) BJAB xenografted mice survival after 200 μg 2C8 or PBS treatment (n = 4). The data are represented as mean ± SEM. (****p < 0.0001; *p < 0.05, multiple t tests).