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. 2021 Jan 5;11:606434. doi: 10.3389/fendo.2020.606434

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Copyright © 2021 Bender, Rajendran and von Herrath

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The healthy human pancreas contains autoreactive CD8 T cells that increase in numbers during diabetes development. Frequencies of PPI-specific CD8 T cells are similar in the exocrine pancreas irrespective of disease status. However, during disease progression, PPI-reactive CD8 T cells become attracted to the islets. The secretion of cytokines, under physiological conditions or stress, may contribute to immune cell recruitment and beta-cell killing. Created with BioRender.com.