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. 2021 Jan 18;11:1666. doi: 10.1038/s41598-021-81076-z

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Comparative analysis of PB and BM cells from control, p62^f/f;Vav, Atg5^f/f;Vav, and Atg5^f/f;p62^f/f;Vav mice. (a) Counts of white blood cells (WBCs), red blood cells (RBCs), and platelets (PLTs) in PB. Data are the mean ± SD (n = 4–7). Each dot indicates values of individual mice. (b) Frequencies of myeloid cells (Mac1⁺Gr-1⁺), T cells (CD4⁺ or CD8⁺), and B cells (B220⁺) in PB. Data are the mean ± SD (n = 3–7). Horizontal line indicates the mean of values. (c) Absolute numbers of CD48⁻CD150⁺LSK cells, multipotent progenitors (MPPs; MPP2/3 and MPP4), common myeloid progenitors (CMPs), granulocyte macrophage progenitors (GMPs), megakaryocyte erythrocyte progenitors (MEPs), and common lymphoid progenitors (CLPs) in BM. Data are mean ± SD (n = 4–8). (d) Absolute numbers of mature B (CD43⁻B220^hiIgM⁺), immature B (CD43⁻B220^loIgM⁺), and pro B/pre B (CD43⁻B220^loIgM⁻) cells in BM. Data are the mean ± SD (n = 3–6).