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. 2021 Jan 18;7:16. doi: 10.1038/s41420-020-00393-w

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Inhibition of AURKB using Barasertib in the early (A–C) and late E-SMGs (D, E). Treatment of the explants with Barasertib for 24h reduced Spooner ratio in the early explants (B) and inhibited expansion of SMG buds in a dose-dependent manner (C, E). Analysis demonstrated gradual reduction of the mean total bud area with increasing doses of Barasertib, which was more clearly seen in the mature explants (late development) (D, E), n = 3 for each group. All downstream experiments were conducted using Barasertib at 1 µM (red outline).