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. 2021 Jan 18;11:1716. doi: 10.1038/s41598-021-81173-z

Figure 2.

Figure 2

Effect of acute ethanol application on evoked GABAA receptor-mediated postsynaptic current (GABAA-ePSC) amplitude and decay in layer V pyramidal neurons and INs. (a) Average ePSC traces from layer V pyramidal neurons during the baseline (black trace) and acute 90 mM ethanol application (blue trace) phases. Scale bars 40 ms, 50 pA. (b) Average ePSC traces from layer V INs during the baseline and acute 90 mM ethanol application phases. Scale bars 40 ms, 20 pA. (c) Normalized GABAA-ePSC amplitudes for both pyramidal neurons (black circles) and INs (red squares) in layer V during the baseline, 90 mM ethanol application, washout, and gabazine (25 µM) application phases. (d) Normalized decay constants (tau) for both pyramidal neurons and INs during the baseline, 90 mM ethanol application and washout phases. Data are presented as mean ± SEM.