Table 1.
Effect of BvRE on ifosfamide-induced nephrotoxicity and oxidative stress on kidney tissue.
| Groups | Serum albumin (g/dL) | Creatinine (mg/dL) | BUN (mg/dL) | MDA (μmol/mL) | GSH (nmol/mg) | CAT (U/mg protein) |
|---|---|---|---|---|---|---|
| Saline-treated control | 4.6 ± 0.21 | 0.66 ± 0.16 | 19.8 ± 4.6 | 1.08 ± 0.2 | 0.36 ± 0.05 | 13.5 ± 1.4 |
| Extract control A | 4.8 ± 0.09x | 0.78 ± 0.13x | 23.8 ± 3.3x | 1.5 ± 0.13x | 0.32 ± 0.06x | 15.59 ± 3.6x |
| Extract control B | 4.6 ± 0.3x | 0.83 ± 0.096x | 21.3 ± 2.5x | 0.97 ± 0.09x | 0.27 ± 0.037x | 13.6 ± 2.3x |
| Ifosfamide control A | 3.1 ± 0.08x | 2.65 ± 0.2x | 79 ± 5.77x | 1.27 ± 0.08x | 0.26 ± 0.05x | 10.8 ± 1.07x |
| Ifosfamide control B | 3.5 ± 0.4x | 2.41 ± 0.43x | 71.8 ± 13x | 1.4 ± 0.2x | 0.25 ± 0.05x | 10.42 ± 1.1x |
| Combination | 3.68 ± 0.17x,y,z | 0.98 ± 0.17x,y,z | 22 ± 2.9x,y,z | 1.04 ± 0.07x,y,z | 0.32 ± 0.02x,y,z | 14.6 ± 1.9x,y,z |
| Curative | 3.48 ± 0.09x,z | 1.18 ± 0.28x,z | 23.3 ± 3.6x,z | 1.42 ± 0.4x,z | 0.33 ± 0.03x,z | 13.6 ± 0.56x,z |
| Prophylactic | 4.38 ± 0.48x,y | 1 ± 0.19x,y | 23.5 ± 2.9x,y | 1.04 ± 0.09x,y | 0.3 ± 0.05x,y | 14.5 ± 4.5x,y |
Descriptive statistics of renal function tests and oxidative stress parameters are represented as mean ± standard deviation of six observations (n = 6); where symbol x denotes a particular group compared with the saline-treated control as p < 0.05. Symbol y signifies the comparison of a particular group with plant controls as p < 0.05, while z expresses the comparison of a particular group with ifosfamide controls as p < 0.05 (one‐way ANOVA followed by post hoc Scheffe test).