Table 5.
Effect of BvRE on ifosfamide-induced neurotoxicity and oxidative stress on brain tissue.
| Groups | AChE (µmol/g) | MDA (µmol/mg) | CAT (U/mg) | GSH (nmol/mg) |
|---|---|---|---|---|
| Saline-treated control | 74.0 ± 10.4 | 0.91 ± 0.025 | 1.92 ± 0.05 | 0.12 ± 0.02 |
| Extract control A | 82.29 ± 18.0x | 0.905 ± 0.062x | 1.89 ± 0.08x | 0.090 ± 0.012x |
| Extract control B | 93.2 ± 6.6x | 0.94 ± 0.13x | 1.91 ± 0.09x | 0.10 ± 0.01x |
| Ifosfamide control A | 63.69 ± 12.92x | 1.791 ± 0.476x | 1.654 ± 0.061x | 0.104 ± 0.014x |
| Ifosfamide control B | 66.0 ± 9.9x | 1.87 ± 0.61x | 1.61 ± 0.06x | 0.08 ± 0.01x |
| Combination | 83.1 ± 11.6x,y,z | 0.85 ± 0.01x,y,z | 2.01 ± 0.12x,y,z | 0.09 ± 0.003x,y,z |
| Curative | 71.7 ± 13.1x,z | 0.99 ± 0.18x,z | 1.81 ± 0.11x,z | 0.12 ± 0.006x,z |
| Prophylactic | 92.3 ± 23.1x,y | 0.92 ± 0.08x,y | 1.99 ± 0.15x,y | 0.12 ± 0.01x,y |
Descriptive statistics of renal function tests and oxidative stress parameters are represented as mean ± standard deviation of six observations (n = 6); where symbol x denotes a particular group compared with the saline-treated control as p < 0.05. Symbol y signifies the comparison of a particular group with plant controls as p < 0.05, while z expresses the comparison of a particular group with ifosfamide controls as p < 0.05 (one‐way ANOVA followed by post hoc Scheffe test).