Table 7.
Effect of BvRE on ifosfamide-induced cardiotoxicity and oxidative stress on heart tissue.
| Groups | LDH (mmol/mg) | MDA (µmol/mg) | GSH (nmol/mg) | CAT (µmol/mg) |
|---|---|---|---|---|
| Saline-treated control | 1.545 ± 0.085 | 1.1 ± 0.024 | 0.044 ± 0.01 | 5.3 ± 0.28 |
| Extract control A | 1.347 ± 0.298x | 0.9 ± 0.04x | 0.04 ± 0.008x | 4.7 ± 0.12x |
| Extract control B | 1.199 ± 0.095x | 0.97 ± 0.03x | 0.038 ± 0.01x | 5.6 ± 0.53x |
| Ifosfamide control A | 3.456 ± 0.264x | 1.36 ± 0.08x | 0.022 ± 0.01x | 5.11 ± 0.35x |
| Ifosfamide control B | 1.823 ± 0.608x | 1.63 ± 0.15x | 0.018 ± 0.009x | 5.4 ± 0.35x |
| Combination | 1.635 ± 0.24x,y,z | 1.18 ± 0.2x,y,z | 0.02 ± 0.01x,y,z | 5.73 ± 0.72x,y,z |
| Curative | 1.339 ± 0.097x,z | 1.3 ± 0.3x,z | 0.04 ± 0.01x,z | 5.36 ± 0.58x,z |
| Prophylactic | 0.807 ± 0.165x,y | 1.01 ± 0.07x,y | 0.032 ± 0.01x,y | 5.44 ± 1.61x,y |
Descriptive statistics of renal function tests and oxidative stress parameters are represented as mean ± standard deviation of six observations (n = 6); where symbol x denotes a particular group compared with the saline-treated control as p < 0.05. Symbol y signifies the comparison of a particular group with plant controls as p < 0.05, while z expresses the comparison of a particular group with ifosfamide controls as p < 0.05 (one‐way ANOVA followed by post hoc Scheffe test).